Constructing Endophenotypes of Complex Diseases Using Non-Negative Matrix Factorization and Adjusted Rand Index

Constructing Endophenotypes of Complex Diseases Using Non-Negative Matrix Factorization and Adjusted Rand Index

Complex diseases are typically caused by combinations of molecular disturbances that vary widely among different patients. Endophenotypes, a combination of genetic factors associated with a disease, offer a simplified approach to dissect complex trait by reducing genetic heterogeneity. Because molecular dissimilarities often exist between patients with indistinguishable disease symptoms, these ...

Non-negative matrix factorization

Email Surveillance Using Non-negative Matrix Factorization

In this study, we apply a non-negative matrix factorization approach for the extraction and detection of concepts or topics from electronic mail messages. For the publicly released Enron electronic mail collection, we encode sparse term-by-message matrices and use a low rank non-negative matrix factorization algorithm to preserve natural data non-negativity and avoid subtractive basis vector an...

A new approach for building recommender system using non negative matrix factorization method

Nonnegative Matrix Factorization is a new approach to reduce data dimensions. In this method, by applying the nonnegativity of the matrix data, the matrix is ​​decomposed into components that are more interrelated and divide the data into sections where the data in these sections have a specific relationship. In this paper, we use the nonnegative matrix factorization to decompose the user ratin...

Bayesian Non-negative Matrix Factorization

We present a Bayesian treatment of non-negative matrix factorization (NMF), based on a normal likelihood and exponential priors, and derive an efficient Gibbs sampler to approximate the posterior density of the NMF factors. On a chemical brain imaging data set, we show that this improves interpretability by providing uncertainty estimates. We discuss how the Gibbs sampler can be used for model ...